Urocortin, human ( ?Urocortin (human) | Human urocortin | Human urocortin 1 | Human urocortin I )

产品货号. M23791 CAS No. 176591-49-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Urocortin, human
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

尿皮质素 (Ucn) 是一种 40 个氨基酸的肽，与促肾上腺皮质激素释放因子 (CRF) 密切相关。
产品描述

Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).
体外实验

Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively.
体内实验

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior.
同义词

?Urocortin (human) | Human urocortin | Human urocortin 1 | Human urocortin I
通路

Others
靶点

Other Targets
受体

CRF2?
研究领域

——
适应症

——

CAS Number

176591-49-4
分子量

4696.32
分子式

C204H337N63O64
纯度

>98% (HPLC)
溶解度

——
SMILES

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
化学全称

——

1.Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.

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